Pre-mRNA splicing: life at the centre of the central dogma.

Numerous studies have demonstrated extensive coupling among different steps in eukaryotic gene expression, the best example being the intimate connection between transcription and RNA processing. More recently, new connections between nuclear and cytoplasmic steps in post-transcriptional gene expression have been established. The central illustration depicts the central dogma of eukaryotic gene expression and highlights the basic steps composing post-transcriptional regulation.